CAS 2437-29-8 | Malachite green oxalate

IKBKE[3]

[1]. Kozuka S, et, al. Permeability of dormant spores of Bacillus subtilis to malachite green and crystal violet. J Gen Microbiol. 1991 Mar; 137(3): 607-13.

[2]. Takahashi S, et, al. Reversible off-on fluorescence probe for hypoxia and imaging of hypoxia-normoxia cycles in live cells. J Am Chem Soc. 2012 Dec 5; 134(48): 19588-91.

[3]. Liu T, et, al. Identification of an IKBKE inhibitor with antitumor activity in cancer cells overexpressing IKBKE. Cytokine. 2019 Apr; 116: 78-87.

CHEMICAL IDENTIFICATION

RTECS NUMBER :

BQ1190000

CAS REGISTRY NUMBER :

2437-29-8

LAST UPDATED :

199710

DATA ITEMS CITED :

7

MOLECULAR FORMULA :

C46-H50-N4.C2-H2-O4.2C2-H-O4

MOLECULAR WEIGHT :

927.10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

275 mg/kg

TOXIC EFFECTS :

Behavioral - changes in motor activity (specific assay) Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes

TYPE OF TEST :

LD - Lethal dose

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>2 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

50 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :

Mutation in microorganisms

TEST SYSTEM :

Bacteria - Salmonella typhimurium

DOSE/DURATION :

40 ug/plate

REFERENCE :

ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 56,43,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2442 No. of Facilities: 6 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 112 (estimated) No. of Female Employees: 41 (estimated)

Methods 77-78 , 63-8, (2015)

PTEN (phosphatase and tensin homologue deleted on chromosome 10) is well known as a tumour suppressor. It's PI(3,4,5)P3 lipid phosphatase activity is an important counteracting mechanism in PI 3-kinas...

Cell Tissue Res. 359(2) , 577-87, (2015)

Tendon calcification is common in the Achilles tendon, and injuries affect not only athletes, but also the general population. However, the underlying cellular mechanisms are not yet fully understood....

Anal. Chim. Acta 761 , 143-8, (2013)

This paper describes the measurement of the binding affinities of two bifunctional RNA aptamers to their respective ligands. The aptamers comprise either a theophylline or malachite green binding sequ...