【 WhatsApp】
+86-21-6420 0566
8618501763615
| OEM | OEM Services Provided |
| Feature | Good stability,Easy to Use |
| Classification | Dyes and Pigments |
| Advantage | Professional, Fast Delivery, Customizable | Samples | Apply for free，Contact us now. |
| Product Name: | 2-Amino-6-methoxybenzothiazole |
| Synonyms: | 2-amino-6-methoxy-benzothiazol;6-methoxy-2-benzothiazolamin;TIMTEC-BB SBB003746;2-AMINO-6-METHOXYBENZOTHIAZOLE;2-AMINO-6-METHOXYBENZOTHIOPHENE;2-BENZOTHIAZOLAMINE, 6-METHOXY-;AKOS BBS-00005696;AKOS AUF2099 |
| CAS: | 1747-60-0 |
| MF: | C8H8N2OS |
| MW: | 180.23 |
| EINECS: | 217-130-0 |
| Product Categories: | Building Blocks;Heterocyclic Building Blocks;Thiazoles;Heterocyclic Compounds;Sulphur Derivatives;Intermediates of Dyes and Pigments;BENZOTHIAZOLE;bc0001 |
| Mol File: | 1747-60-0.mol |
| Melting point | 165-167 °C (lit.) |
| Boiling point | 240°C |
| density | 1.2425 (rough estimate) |
| refractive index | 1.5690 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | very slightly in Methanol |
| pka | pK1: 4.50(+1) (25°C) |
| form | Crystalline Powder |
| color | White to beige |
| Water Solubility | <0.1 g/100 mL at 21 ºC |
| Stability: | Stable, but may be light sensitive. Incompatible with strong oxidizing agents. |
| InChI | InChI=1S/C8H8N2OS/c1-11-5-2-3-6-7(4-5)12-8(9)10-6/h2-4H,1H3,(H2,9,10) |
| InChIKey | KZHGPDSVHSDCMX-UHFFFAOYSA-N |
| SMILES | S1C2=CC(OC)=CC=C2N=C1N |
| CAS DataBase Reference | 1747-60-0(CAS DataBase Reference) |
| EPA Substance Registry System | 2-Amino-6-methoxybenzothiazole (1747-60-0) |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38-20/21/22 |
| Safety Statements | 26-36 |
| RIDADR | 2811 |
| WGK Germany | 3 |
| RTECS | DL2100000 |
| TSCA | Yes |
| HazardClass | IRRITANT |
| PackingGroup | III |
| HS Code | 29342080 |
| Toxicity | mouse,LD50,intravenous,140mg/kg (140mg/kg),Journal of Pharmacology and Experimental Therapeutics. Vol. 105, Pg. 486, 1952. |
| Provider | Language |
|---|---|
| 6-Methoxy-2-aminobenzothiazole | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| Uses | 2-Amino-6-methoxybenzothiazole is an intermediate used to prepare novel series of Schiff bases and 4-thiazolidinones. It is also used in the synthesis of 2-cyano-6-methoxybenzothiazole. |
| off-white to tan-coloured powder | |
| Uses | 2-Amino-6-methoxybenzothiazole was used as building block in the syntheses of novel series of Schiff bases and 4-thiazolidinones. It was used in the synthesis of 2-cyano-6-methoxybenzothiazole, key intermediate for the synthesis of firefly luciferin. |
| Fine off-white to light tan powder. | |
| Air & Water Reactions | Insoluble in water. |
| 2-Amino-6-methoxybenzothiazole may be sensitive to exposure to light. 2-Amino-6-methoxybenzothiazole is incompatible with strong oxidizers. | |
| Fire Hazard | Flash point data for 2-Amino-6-methoxybenzothiazole are not available; however, 2-Amino-6-methoxybenzothiazole is probably combustible. |
333-20-0 104-94-9 1747-60-0 0.1 mole of p-aminoanisole and 0.1 mole of potassium thiocyanate (KCNS) were dissolved in 100 mL of glacial acetic acid (AcOH) and the mixture was cooled and stirred in an ice bath for 10-20 minutes. Subsequently, 0.1 mol of bromine in glacial acetic acid solution was slowly added dropwise, with the rate of dropwise acceleration controlled to maintain the reaction temperature below 10 °C. After the dropwise addition was completed, the reaction mixture was stirred at room temperature for 2-4 hours. After completion of the reaction, the resulting hydrobromide (HBr) salt was separated by filtration, washed with glacial acetic acid and dried. The dried salt was dissolved in hot water and alkalized by adjusting the pH to 11.0 with ammonia solution (NH4OH). The precipitate precipitated was filtered, washed with water and dried to give the target product 2-amino-6-methoxybenzothiazole. The reaction process was monitored by thin layer chromatography (TLC) using toluene: acetone (8:2) as unfolding agent. | |
| References | [1] Synlett, 2012, vol. 23, # 15, p. 2219 - 2222 [2] Synlett, 2009, # 16, p. 2682 - 2684 [3] Heterocyclic Communications, 2018, vol. 24, # 5, p. 255 - 258 [4] Phosphorus, Sulfur and Silicon and the Related Elements, 2008, vol. 183, # 5, p. 1124 - 1133 [5] European Journal of Medicinal Chemistry, 2008, vol. 43, # 5, p. 1114 - 1122 |
| Raw materials | Aniline-->Water-->p-Anisidine-->Sodium thiocyanate-->Congo red paper-->Disulfur dichloride-->4-METHOXYPHENYLTHIOUREA-->Phenolphthalein |
| Preparation Products | BASIC BLUE 41 (C.I. 11105)-->Catonic Dark Yellow 2RL-->6-Methoxy-3-methyl-2(3H)-benzothiazolone hydrazone-->Basic Blue 162-->2-Amino-6-ethoxybenzothiazole-->2-Cyano-6-methoxybenzothiazole-->BASIC BLUE 41-->SUPRACET BRILLIANT RED BD-->Basic Blue 162-->3-(3-amino-3-oxopropyl)-2-[[4-[bis(2-chloroethyl)amino]phenyl]azo]-6-methoxybenzothiazolium chloride-->1,2,3,4-Tetrahydro-6-[(6-methoxybenzothiazol-2-yl)azo]benzo[h]quinoline-3,7-diol-->BASIC YELLOW 19 |
Declaration: The products displayed on this website are intended exclusively for industrial applications or scientific research. They are not intended for medical, pharmaceutical, or food use. In accordance with applicable laws and regulations, purchasing organizations must hold valid qualifications and approvals.
Ready to Start?
For help with solutions customized to your business needs, contact Export Director now.
With 30+ years of experience and We firmly believe that product quality is the basis of cooperation.
Chat Now
Phone
8618501763615
Working hours
Monday to Friday
TEl
+86-21-6420 0566
